Oscar Millet Selected Research

Uroporphyrinogen III Synthetase (Uroporphyrinogen-III Synthase)

6/2021	Identification of novel UROS mutations in a patient with congenital erythropoietic porphyria and efficient treatment by phlebotomy.
5/2021	Improving the Pharmacological Properties of Ciclopirox for Its Use in Congenital Erythropoietic Porphyria.
1/2018	Repurposing ciclopirox as a pharmacological chaperone in a model of congenital erythropoietic porphyria.
1/2017	Missense UROS mutations causing congenital erythropoietic porphyria reduce UROS homeostasis that can be rescued by proteasome inhibition.
11/2014	Tuning intracellular homeostasis of human uroporphyrinogen III synthase by enzyme engineering at a single hotspot of congenital erythropoietic porphyria.
11/2013	Therapeutic potential of proteasome inhibitors in congenital erythropoietic porphyria.
4/2011	Intracellular rescue of the uroporphyrinogen III synthase activity in enzymes carrying the hotspot mutation C73R.
1/2011	Structural, thermodynamic, and mechanistical studies in uroporphyrinogen III synthase: molecular basis of congenital erythropoietic porphyria.
1/2009	Uroporphyrinogen III synthase mutations related to congenital erythropoietic porphyria identify a key helix for protein stability.

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Oscar Millet Research Topics

Disease

10	Erythropoietic Porphyria (Congenital Erythropoietic Porphyria) 06/2021 - 01/2009
6	Fibrosis (Cirrhosis) 10/2022 - 01/2016
4	COVID-19 01/2022 - 01/2020
3	Non-alcoholic Fatty Liver Disease 10/2022 - 01/2021
3	Infections 01/2022 - 12/2020
2	Liver Cirrhosis (Hepatic Cirrhosis) 01/2022 - 01/2017
2	Liver Diseases (Liver Disease) 01/2022 - 01/2017
2	Tyrosinemias (Tyrosinemia) 02/2021 - 01/2019
2	Hemolytic Anemia 01/2017 - 11/2013
1	Cardiovascular Diseases (Cardiovascular Disease) 01/2022
1	Inflammation (Inflammations) 01/2022
1	Mitochondrial Diseases (Mitochondrial Disease) 01/2022
1	Severe Acute Respiratory Syndrome 01/2022
1	Disease Progression 12/2021
1	Respiratory Tract Infections (Respiratory Tract Infection) 07/2021
1	Anemia 06/2021
1	Starvation 01/2021
1	Insulin Resistance 01/2021
1	Congenital, Hereditary, and Neonatal Diseases and Abnormalities (Congenital Disorders) 01/2021
1	Rare Diseases (Rare Disease) 01/2021
1	Neoplasms (Cancer) 01/2020
1	Prostatic Neoplasms (Prostate Cancer) 01/2020
1	Trimethylaminuria 10/2019
1	Ketosis 10/2019
1	X-Linked Bulbo-Spinal Atrophy 01/2019
1	Acute Intermittent Porphyria (Porphyria, Acute) 11/2018
1	Pathologic Processes 05/2014

Drug/Important Bio-Agent (IBA)

9	Uroporphyrinogen III Synthetase (Uroporphyrinogen-III Synthase)IBA 06/2021 - 01/2009
7	EnzymesIBA 10/2022 - 01/2011
5	PorphyrinsIBA 01/2022 - 11/2013
5	Biomarkers (Surrogate Marker)IBA 01/2022 - 01/2016
5	Heme (Haem)IBA 06/2021 - 01/2011
3	Proteins (Proteins, Gene)FDA Link 10/2022 - 05/2014
3	Phospholipids (Phosphatides)FDA LinkGeneric 01/2022 - 01/2021
3	Lipoproteins (Lipoprotein)IBA 01/2022 - 01/2021
3	Choline (Choline Chloride)IBA 01/2022 - 01/2016
2	Polysaccharides (Glycans)IBA 01/2022 - 12/2020
2	Methionine AdenosyltransferaseIBA 01/2022 - 01/2021
2	ApolipoproteinsIBA 01/2022 - 01/2021
2	Ciclopirox (Loprox)FDA LinkGeneric 05/2021 - 01/2018
2	acetoacetic acid (acetoacetate)IBA 02/2021 - 01/2016
2	Pharmaceutical PreparationsIBA 01/2018 - 05/2014
2	Proteasome InhibitorsIBA 01/2017 - 11/2013
1	very low density lipoprotein triglycerideIBA 10/2022
1	Phospholipases (Phospholipase)IBA 10/2022
1	Carbon Tetrachloride (Tetrachloromethane)IBA 01/2022
1	Glycoproteins (Glycoprotein)IBA 01/2022
1	Carnitine O-Palmitoyltransferase (Carnitine Palmitoyltransferase II)IBA 01/2022
1	IsomerasesIBA 01/2022
1	Methionine (L-Methionine)FDA Link 01/2022
1	Phosphotransferases (Kinase)IBA 01/2022
1	Protons (Proton)IBA 01/2022
1	Bovine Serum AlbuminIBA 01/2022
1	VaccinesIBA 01/2022
1	Transforming Growth Factors (Transforming Growth Factor)IBA 01/2022
1	Fatty Acids (Saturated Fatty Acids)IBA 01/2022
1	LipidsIBA 07/2021
1	Ferritins (Ferritin)IBA 06/2021
1	fumarylacetoacetateIBA 02/2021
1	succinylacetoneIBA 02/2021
1	HydrolasesIBA 02/2021
1	HDL LipoproteinsIBA 01/2021
1	IronIBA 01/2021
1	Insulin (Novolin)FDA Link 01/2021
1	Glucose (Dextrose)FDA LinkGeneric 01/2021
1	LectinsIBA 12/2020
1	CarbonIBA 01/2020
1	NitrogenIBA 01/2020
1	Urea (Carbamide)FDA LinkGeneric 01/2020
1	trimethylamineIBA 10/2019
1	fumarylacetoacetase (fumarylacetoacetate hydrolase)IBA 01/2019
1	polyglutamineIBA 01/2019
1	Androgen Receptors (Androgen Receptor)IBA 01/2019
1	Tyrosine (L-Tyrosine)FDA Link 01/2019
1	Hydroxymethylbilane Synthase (Porphobilinogen Deaminase)IBA 11/2018
1	Proteasome Endopeptidase Complex (Proteasome)IBA 01/2017
1	SphingomyelinsIBA 01/2017
1	Bile Acids and Salts (Bile Acids)IBA 01/2017
1	LDL Lipoproteins (beta Lipoproteins)IBA 01/2016

Therapy/Procedure

1	Therapeutics 01/2017
1	Liver Transplantation 01/2017